Coma Associated with Vincristine Therapy

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Coma associated with vincristine therapy.

Three cases of coma after vincristine therapy are described. One patient had hyponatraemia and other features of inappropriate secretion of antidiuretic hormone. The effects were temporary, and full recovery occurred in all three patients.

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Experience with vincristine--associated neurotoxicity.

OBJECTIVES To evaluate the frequency and severity of occurrence of vincristine-associated neurotoxicity. DESIGN A retrospective case series study. SETTING Hurlingham Oncology Clinic, Nairobi. SUBJECTS Thirty-eight patients treated for various neoplasms with vincristine containing chemotherapeutic regimens. MAIN OUTCOME MEASURES The frequency and degree of neurotoxicity when vincristine ...

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Hypoglycaemic coma associated with gastric carcinoma.

Gastric carcinoma may rarely be the cause of tumour-associated hypoglycaemia. We report the case of an elderly woman who presented in hypoglycaemic coma, and who was found subsequently to have an adenocarcinoma of the stomach. Hypoglycaemia persisted despite prednisolone, diazoxide, and a high concentration dextrose infusion. The few published cases are reviewed in which an association was esta...

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Hypoglycaemic coma associated with gastric carcinoma lain

Gastric carcinoma may rarely be the cause of tumour-associated hypoglycaemia. We report the case of an elderly woman who presented in hypoglycaemic coma, and who was found subsequently to have an adenocarcinoma of the stomach. Hypoglycaemia persisted despite prednisolone, diazoxidef and a high concentration dextrose infusion. The few published cases are reviewed in which an association was esta...

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Spironolactone-associated hyponatremic coma.

Dr. Michael M. Hirschl, Department of Emergency Medicine, New General Hospital, Währinger Gürtel 18-20, A-1090 Vienna (Austria) Admission Dear Sir, Hyponatremia is the most common electrolyte abnormality observed in a general hospitalized population, seen in about 2% of patients [1]. Common causes of hyponatremia are the syndrome of inappropriate secretion of antidiuretic hormone, water intoxic...

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ژورنال

عنوان ژورنال: BMJ

سال: 1973

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.4.5888.335